International Research in Infectious Diseases, including AIDS

The purpose of this Funding Opportunity Announcement (FOA) is to encourage the submission of R01 applications from institutions in eligible foreign countries to conduct studies in infectious disease research. Collaborations with investigators in the United States (U.S.) are encouraged but not required. These grants will serve to build independent research capacity by providing direct funding to investigators who do not currently have NIH-funded grant or contract awards for research projects. The intent of these activities is to advance the development of local scientific expertise.

NIAID has a long-standing interest in and commitment to global health and international research. Topics of interest for this program are limited to research on infectious diseases, including emerging infections that are of public health significance within the applicant country (including but not limited to: tuberculosis; malaria; influenza; HIV/AIDS; sexually transmitted diseases; diarrheal, respiratory, and enteric diseases; viral hemorrhagic fevers; viral encephalitides; other viral diseases, parasitic diseases; vector-borne diseases, and development of drug resistance). Development of basic, immunological, microbiological, biostatistical, epidemiological, data management, and clinical research capacity is encouraged. 

Research Objectives and Scope
Studies may be proposed on any aspect of infectious disease research (except clinical trials), including but not limited to: the epidemiology, natural history, pathogenesis, immunopathogenesis of infectious diseases; epidemiologic studies to define the incidence, clinical presentations, and outcomes of diseases; identification of resistance patterns; characterization of susceptible cohorts for a particular pathogen; pilot and feasibility studies in preparation for larger studies. NOTE: HIV/AIDS studies must address NIAID priorities described at
Collaborative projects involving investigators and institutions from international sites and the U.S. are particularly encouraged; however, a U.S. partner is not required. NIH supports a number of international research programs on infectious diseases, including HIV/AIDS. For NIAID, these include the International Centers of Excellence in Research (ICERs), International Collaborations for Infectious Disease Research (ICIDRs), the Tropical Medicine Research Centers (TMRCs), the Centers of Excellence for Influenza Research and Surveillance (CEIRS), the International Centers of Excellence for Malaria Research (ICEMRS), the Tuberculosis Research Unit, the HIV Vaccine Trials Network (HVTN), the HIV Prevention Trials Network (HPTN),  International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT), AIDS Clinical Trials Group (ACTG), Microbicide Trials Network (MTN), International Network for Strategic Initiatives in Global HIV Trials (INSIGHT),  the International Epidemiologic Database to Evaluate AIDS (IeDEA), and the Centers for AIDS Research (CFAR).

This International Research in Infectious Diseases including AIDS (IRIDA) Program (R01) is intended to extend these programs by expanding the breadth of research supported at international sites and by providing support to new researchers. Applications are particularly encouraged from institutions in eligible countries where NIH has significant investments through extramural research grants, cooperative agreements or contracts or through NIH intramural programs. Current NIH or NIAID funding is not a requirement.

Applicants are strongly encouraged to establish multi-institutional collaborations and to include in their research plans activities that involve the transfer of technologies and research methods, sharing of core resources including the administration of research grant programs, and expansion of linkages to other sites via attendance at national and international meetings and other methods of communication.

  • Resource-constrained Non-domestic (non-U.S.) Entities (Foreign Organizations) ONLY
  • Non-domestic (non-U.S.) Entities (Foreign Institutions) from resource-constrained countries are eligible to apply.
    Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
  • Foreign components, as defined in the NIH Grants Policy Statement, are not allowed
  • Applicant organizations must be headquartered in foreign (non-U.S.) resource-constrained countries (i.e. low-income economies, lower-middle-income economies, and upper-middle-income economies by World Bank definition).  To determine the eligibility status of a country

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